Getting the Hologenome Concept Right: an Eco-Evolutionary Framework for Hosts and Their Microbiomes.

Theis, Kevin R., Dheilly, Nolwenn M., Klassen, Jonathan L., Brucker, Robert M., Baines, John F., Bosch, Thomas, Cryan, John F., Gilbert, Scott F., Goodnight, Charles J., Lloyd, Elisabeth A., Sapp, Jan, Vandenkoornhuyse, Philippe, Zilber-Rosenberg, Ilana, Rosenberg, Eugene, Bordenstein, Seth R. and Gilbert, Jack A. (2016) Getting the Hologenome Concept Right: an Eco-Evolutionary Framework for Hosts and Their Microbiomes. mSystems, 1 (2). e00028-16. DOI 10.1128/mSystems.00028-16.

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Abstract

Given the complexity of host-microbiota symbioses, scientists and philosophers are asking questions at new biological levels of hierarchical organization—what is a holobiont and hologenome? When should this vocabulary be applied? Are these concepts a null hypothesis for host-microbe systems or limited to a certain spectrum of symbiotic interactions such as host-microbial coevolution? Critical discourse is necessary in this nascent area, but productive discourse requires that skeptics and proponents use the same lexicon. For instance, critiquing the hologenome concept is not synonymous with critiquing coevolution, and arguing that an entity is not a primary unit of selection dismisses the fact that the hologenome concept has always embraced multilevel selection. Holobionts and hologenomes are incontrovertible, multipartite entities that result from ecological, evolutionary, and genetic processes at various levels. They are not restricted to one special process but constitute a wider vocabulary and framework for host biology in light of the microbiome.

Document Type: Article
Keywords: ecology, evolution, hologenome, microbiome
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence > FO-R08
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1128/mSystems.00028-16
ISSN: 2379-5077
Projects: Future Ocean
Date Deposited: 28 Mar 2017 11:03
Last Modified: 23 Sep 2019 22:47
URI: http://oceanrep.geomar.de/id/eprint/37233

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