Review – Lichen-Associated Bacteria as a Hot Spot of Chemodiversity: Focus on Uncialamycin, a Promising Compound for Future Medicinal Applications.

Parrot, Delphine, Legrave, Nathalie, Delmail, David, Grube, Martin, Suzuki, Marcelino and Tomasi, Sophie (2016) Review – Lichen-Associated Bacteria as a Hot Spot of Chemodiversity: Focus on Uncialamycin, a Promising Compound for Future Medicinal Applications. Planta Medica, 82 (13). pp. 1143-1152. DOI 10.1055/s-0042-105571.

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Abstract

This review presents the state of knowledge on the medicinal potential of bacteria associated with lichens. In fact, besides the classical symbiotic partners (photobiont and mycobiont) forming the lichen thallus, associated bacteria have been recently described as a third partner. Various studies demonstrated the diversity of these communities with a predominance of Alphaproteobacteria. Bacterial groups more relevant for secondary metabolite synthesis have also been revealed. This article summarizes studies reporting the abilities of these communities to produce metabolites with relevant bioactivities. The biotechnological interest of these bacteria for drug discovery is highlighted regarding the production of compounds with therapeutic potential. Special focus is given to the synthesis of the most promising compound, uncialamycin, a potent enediyne isolated from a Streptomyces sp. associated with Cladonia uncialis.

Document Type: Article
Keywords: lichens - bacterial communities - chemodiversity - drug discovery - bioactive compounds - uncialamycin
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1055/s-0042-105571
ISSN: 0032-0943
Date Deposited: 15 Jun 2017 07:41
Last Modified: 01 Feb 2019 14:59
URI: http://oceanrep.geomar.de/id/eprint/38380

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