Physiology, pathophysiology, and clinical impact of claudins.

Bleich, M. and Günzel, D. (2017) Physiology, pathophysiology, and clinical impact of claudins. Pflügers Archiv - European Journal of Physiology, 469 (1). pp. 1-2. DOI 10.1007/s00424-016-1918-2.

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Life and disease of an organism are determined by homeostatic mechanisms which secure the composition of body fluids, temperature, and regulation of growth and metabolism. It also includes the control of interfaces between the organism and its environment. Here, epithelial function plays a central role. The layers of epithelial cells of outer and inner body surfaces serve two opposing goals: tightening and permeation. Barrier formation against pathogen invasion or loss of fluids and on the other hand simultaneous massive transepithelial transport of substrates, salts, and water require specific properties. Although the paracellular pathway has always been a part of our understanding of epithelial function [2], it became clear only recently that the perspective on its role changed from a passive barrier to an actively fine-tuned functional component of every epithelium. In addition, it became evident that either causes or symptoms of widespread diseases like cancer, dermatitis, nephrolithiasis, epithelial infections, and diarrhea emerge from a dysfunctional tight junctional proteome.

Document Type: Article
Research affiliation: Kiel University
Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1007/s00424-016-1918-2
ISSN: 0031-6768
Projects: Future Ocean
Date Deposited: 17 Oct 2017 11:42
Last Modified: 23 Sep 2019 20:41

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