Host modification of a bacterial quorum-sensing signal induces a phenotypic switch in bacterial symbionts.

Pietschke, C., Treitz, C., Forêt, S., Schultze, A., Künzel, S., Tholey, Andreas, Bosch, T. C. G. and Fraune, Sebastian (2017) Host modification of a bacterial quorum-sensing signal induces a phenotypic switch in bacterial symbionts. Proceedings of the National Academy of Sciences, 114 (40). E8488-E8497. DOI 10.1073/pnas.1706879114.

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Supplementary data:

Abstract

Bacterial communities colonize epithelial surfaces of most animals. Several factors, including the innate immune system, mucus composition, and diet, have been identified as determinants of host-associated bacterial communities. Here we show that the early branching metazoan Hydra is able to modify bacterial quorum-sensing signals. We identified a eukaryotic mechanism that enables Hydra to specifically modify long-chain 3-oxo-homoserine lactones into their 3-hydroxy-HSL counterparts. Expression data revealed that Hydra’s main bacterial colonizer, Curvibacter sp., responds differentially to N-(3-hydroxydodecanoyl)-l-homoserine lactone (3OHC12-HSL) and N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL). Investigating the impacts of the different N-acyl-HSLs on host colonization elucidated that 3OHC12-HSL allows and 3OC12-HSL represses host colonization of Curvibacter sp. These results show that an animal manipulates bacterial quorum-sensing signals and that this modification leads to a phenotypic switch in the bacterial colonizers. This mechanism may enable the host to manipulate the gene expression and thereby the behavior of its bacterial colonizers.

Document Type: Article
Keywords: Hydra quorum quenching quorum sensing interference host–microbe interaction
Research affiliation: Kiel University
Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: Yes
DOI etc.: 10.1073/pnas.1706879114
ISSN: 0027-8424
Projects: Future Ocean
Date Deposited: 17 Oct 2017 12:21
Last Modified: 23 Sep 2019 20:23
URI: http://oceanrep.geomar.de/id/eprint/39943

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