A secreted antibacterial neuropeptide shapes the microbiome of Hydra.

Augustin, R., Schröder, K., Murillo Rincón, A. P., Fraune, Sebastian, Anton-Erxleben, F., Herbst, E.-M., Wittlieb, J., Schwentner, M., Grötzinger, J., Wassenaar, T. M. and Bosch, T. C. G. (2017) A secreted antibacterial neuropeptide shapes the microbiome of Hydra. Nature Communications, 8 (1). DOI 10.1038/s41467-017-00625-1.

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Supplementary data:

Abstract

Colonization of body epithelial surfaces with a highly specific microbial community is a fundamental feature of all animals, yet the underlying mechanisms by which these communities are selected and maintained are not well understood. Here, we show that sensory and ganglion neurons in the ectodermal epithelium of the model organism hydra (a member of the animal phylum Cnidaria) secrete neuropeptides with antibacterial activity that may shape the microbiome on the body surface. In particular, a specific neuropeptide, which we call NDA-1, contributes to the reduction of Gram-positive bacteria during early development and thus to a spatial distribution of the main colonizer, the Gram-negative Curvibacter sp., along the body axis. Our findings warrant further research to test whether neuropeptides secreted by nerve cells contribute to the spatial structure of microbial communities in other organisms.

Document Type: Article
Keywords: Antimicrobials, Microbiome, Neuroimmunology, Symbiosis
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: Yes
DOI etc.: 10.1038/s41467-017-00625-1
ISSN: 2041-1723
Projects: Future Ocean
Date Deposited: 17 Oct 2017 12:24
Last Modified: 15 Apr 2019 11:31
URI: http://oceanrep.geomar.de/id/eprint/39944

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