Expansion of the redox-sensitive proteome coincides with the plastid endosymbiosis.

Wöhle, Christian, Dagan, Tal, Landan, Giddy, Vardi, Assaf and Rosenwasser, Shilo (2017) Expansion of the redox-sensitive proteome coincides with the plastid endosymbiosis. Nature Plants, 3 (6). p. 17066. DOI 10.1038/nplants.2017.66.

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Supplementary data:

Abstract

The redox-sensitive proteome (RSP) consists of protein thiols that undergo redox reactions, playing an important role in coordinating cellular processes. Here, we applied a large-scale phylogenomic reconstruction approach in the model diatom Phaeodactylum tricornutum to map the evolutionary origins of the eukaryotic RSP. The majority of P. tricornutum redox-sensitive cysteines (76%) is specific to eukaryotes, yet these are encoded in genes that are mostly of a prokaryotic origin (57%). Furthermore, we find a threefold enrichment in redox-sensitive cysteines in genes that were gained by endosymbiotic gene transfer during the primary plastid acquisition. The secondary endosymbiosis event coincides with frequent introduction of reactive cysteines into existing proteins. While the plastid acquisition imposed an increase in the production of reactive oxygen species, our results suggest that it was accompanied by significant expansion of the RSP, providing redox regulatory networks the ability to cope with fluctuating environmental conditions.

Document Type: Article
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence > FO-R08
Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1038/nplants.2017.66
ISSN: 2055-0278
Projects: Future Ocean
Date Deposited: 14 Dec 2017 14:08
Last Modified: 23 Sep 2019 23:56
URI: http://oceanrep.geomar.de/id/eprint/40661

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