Temperate phages as self-replicating weapons in bacterial competition.

Li, Xiang-Yi, Lachnit, Tim, Fraune, Sebastian, Bosch, T. C. G., Traulsen, Arne and Sieber, Michael (2017) Temperate phages as self-replicating weapons in bacterial competition. Journal of The Royal Society Interface, 14 (137). p. 20170563. DOI 10.1098/rsif.2017.0563.

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Abstract

Microbial communities are accompanied by a diverse array of viruses. Through infections of abundant microbes, these viruses have the potential to mediate competition within the community, effectively weakening competitive interactions and promoting coexistence. This is of particular relevance for host-associated microbial communities, because the diversity of the microbiota has been linked to host health and functioning. Here, we study the interaction between two key members of the microbiota of the freshwater metazoan Hydra vulgaris. The two commensal bacteria Curvibacter sp. and Duganella sp. protect their host from fungal infections, but only if both of them are present. Coexistence of the two bacteria is thus beneficial for Hydra. Intriguingly, Duganella sp. appears to be the superior competitor in vitro due to its higher growth rate when both bacteria are grown separately, but in co-culture the outcome of competition depends on the relative initial abundances of the two species. The presence of an inducible prophage in the Curvibacter sp. genome, which is able to lytically infect Duganella sp., led us to hypothesize that the phage modulates the interaction between these two key members of the Hydra microbiota. Using a mathematical model, we show that the interplay of the lysogenic life cycle of the Curvibacter phage and the lytic life cycle on Duganella sp. can explain the observed complex competitive interaction between the two bacteria. Our results highlight the importance of taking lysogeny into account for understanding microbe–virus interactions and show the complex role phages can play in promoting coexistence of their bacterial hosts.

Document Type: Article
Keywords: bacterial competition bacteria–phage interactions mathematical modelling lysogenic and lytic cycles
Research affiliation: Kiel University
Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1098/rsif.2017.0563
ISSN: 1742-5689
Projects: Future Ocean
Date Deposited: 03 Apr 2018 08:38
Last Modified: 24 Sep 2019 00:07
URI: http://oceanrep.geomar.de/id/eprint/42554

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