First Evidence of Dehydroabietic Acid Production by a Marine Phototrophic Gammaproteobacterium, the Purple Sulfur Bacterium Allochromatium vinosum MT86.

Imhoff, Johannes F. , Sun, Mingshuang, Wiese, Jutta , Tank, Marcus and Zeeck, Axel (2018) First Evidence of Dehydroabietic Acid Production by a Marine Phototrophic Gammaproteobacterium, the Purple Sulfur Bacterium Allochromatium vinosum MT86. Open Access Marine Drugs, 16 (8). Art.Nr. 270. DOI 10.3390/md16080270.

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Abstract

The production of secondary metabolites by a new isolate of the purple sulfur bacterium Allochromatium vinosum, which had shown antibiotic activities during a preliminary study, revealed the production of several metabolites. Growth conditions suitable for the production of one of the compounds shown in the metabolite profile were established and compound 1 was purified. The molecular formula of compound 1 (C20H28O2) was determined by high resolution mass spectra, and its chemical structure by means of spectroscopic methods. The evaluation of these data revealed that the structure of the compound was identical to dehydroabietic acid, a compound known to be characteristically produced by conifer trees, but so far not known from bacteria, except cyanobacteria. The purified substance showed weak antibiotic activities against Bacillus subtilis and Staphylococcus lentus with IC50 values of 70.5 µM (±2.9) and 57.0 µM (±3.3), respectively.

Document Type: Article
Keywords: anoxygenic phototrophic bacteria (APB); Allochromatium vinosum; secondary metabolites; dehydroabietic acid; antibiotic
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence > FO-R03
OceanRep > GEOMAR > FB2 Marine Biogeochemistry > FB2-CH Chemical Oceanography
OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: Yes
DOI etc.: 10.3390/md16080270
ISSN: 1660-3397
Related URLs:
Projects: Future Ocean, Inflammation at Interfaces
Date Deposited: 20 Aug 2018 09:58
Last Modified: 24 May 2019 12:40
URI: http://oceanrep.geomar.de/id/eprint/44037

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