Isolation by Miniaturized Culture Chip of an Antarctic bacterium Aequorivita sp. with antimicrobial and anthelmintic activity.

Palma Esposito, Fortunato, Ingham, Colin J., Hurtado-Ortiz, Raquel, Bizet, Chantal, Tasdemir, Deniz and de Pascale, Donatella (2018) Isolation by Miniaturized Culture Chip of an Antarctic bacterium Aequorivita sp. with antimicrobial and anthelmintic activity. Open Access Biotechnology Reports, 20 . e00281. DOI 10.1016/j.btre.2018.e00281.

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Abstract

Microbes are prolific sources of bioactive molecules; however, the cultivability issue has severely hampered access to microbial diversity. Novel secondary metabolites from as-yet-unknown or atypical microorganisms from extreme environments have realistic potential to lead to new drugs with benefits for human health. Here, we used a novel approach that mimics the natural environment by using a Miniaturized Culture Chip allowing the isolation of several bacterial strains from Antarctic shallow water sediments under near natural conditions. A Gram-negative Antarctic bacterium belonging to the genus Aequorivita was subjected to further analyses. The Aequorivita sp. genome was sequenced and a bioinformatic approach was applied to identify biosynthetic gene clusters. The extract of the Aequorivita sp. showed antimicrobial and anthelmintic activity towards Multidrug resistant bacteria and the nematode Caenorhabditis elegans. This is the first multi-approach study exploring the genomics and biotechnological potential of the genus Aequorivita that is a promising candidate for pharmaceutical applications.

Document Type: Article
Funder compliance: info:eu-repo/grantAgreement/EC/H2020/721421
Keywords: Aequorivita; Antarctic bacteria; Miniaturized culture chip; Multidrug resistant bacteria; Genome mining; Antimicrobial; Anthelmintic
Research affiliation: OceanRep > GEOMAR > Applied R&D > GEOMAR-Biotech
OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MN Marine natural products chemistry
Refereed: Yes
Open Access Journal?: Yes
DOI etc.: 10.1016/j.btre.2018.e00281
ISSN: 2215-017X
Projects: MarPipe
Date Deposited: 24 Sep 2018 07:11
Last Modified: 17 Dec 2018 08:32
URI: http://oceanrep.geomar.de/id/eprint/44363

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