Metabolic modelling of mixed culture anaerobic microbial processes.

Batstone, D. J. , Hülsen, T. and Oehmen, A. (2019) Metabolic modelling of mixed culture anaerobic microbial processes. Current Opinion in Biotechnology, 57 . pp. 137-144. DOI 10.1016/j.copbio.2019.03.014.

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Abstract

Mixed culture anaerobic processes are important to environmental systems, including the global carbon cycle, and industrial and environmental biotechnology. Mixed culture metabolic modelling (MM) is an essential tool to analyse these systems. MM predicts microbial function based on knowledge or assumption of cellular metabolism. It may be developed based on observations at the process level – biochemical process modelling (BPM) or fundamental knowledge of the cell being modelled – cellular level modelling (CLM). There is a substantial gap between these two fields, with BPM not considering genetic constraints, particularly where this may be important to interspecies interactions (e.g. amino acid transfer), and CLM commonly not considering mass transfer principles, such as advection/diffusion/migration. No unified approach is useful for all applications, but there is an increasing need to consider genetic information and constraints in developing BPM, and translate BPM principles (including mass-transfer and inorganic chemistry) for application to CLM.

Document Type: Article
Keywords: Multispecies metabolic modelling, anaerobic processes
Refereed: Yes
Open Access Journal?: No
Publisher: Elsevier
Projects: Enrichment
Date Deposited: 21 May 2019 13:46
Last Modified: 02 Jan 2020 12:13
URI: https://oceanrep.geomar.de/id/eprint/46767

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