Structures and biological activities of cycloheptamycins A and B.

Qian, Zhengyi, Antosch, Janine, Wiese, Jutta , Imhoff, Johannes F. , Fiedler, Hans-Peter, Pöthig, Alexander and Gulder, Tobias A. M. (2019) Structures and biological activities of cycloheptamycins A and B. Organic & Biomolecular Chemistry, 17 (27). pp. 6595-6600. DOI 10.1039/c9ob01261c.

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Abstract

The heptadepsipeptide cycloheptamycin A was isolated from the terrestrial Streptomyces sp. Tü 6314. Its constitution was elucidated on the basis of NMR spectroscopic experiments and mass spectrometric analysis. Its stereostructure was investigated by peptide hydrolysis and derivatization and firmly established by X-ray structure analysis. In addition to the parent compound, a new cycloheptamycin analog, cycloheptamycin B, was discovered and structurally assigned using comparative MS/MS experiments and NMR. The biological profile of both compounds was investigated, revealing a selective inhibitory potential of cycloheptamycins against Propionibacterium acnes.

Document Type: Article
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MS Marine Symbioses
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1039/c9ob01261c
ISSN: 1477-0520
Date Deposited: 03 Jul 2019 09:56
Last Modified: 22 Jul 2019 10:34
URI: http://oceanrep.geomar.de/id/eprint/47095

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