Comparison of the effects of fucoidans on cell viability of tumor and non-tumor cell lines.

Bittkau, Kaya S., Dörschmann, Philipp, Blümel, Martina, Tasdemir, Deniz , Roider, Johann, Klettner, Alexa Karina and Alban, Susanne (2019) Comparison of the effects of fucoidans on cell viability of tumor and non-tumor cell lines. Open Access Marine Drugs, 17 . Art.Nr. 441. DOI 10.3390/md17080441.

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Fucoidans extracted from brown algae exert manifold biological activities paving the way for the development of numerous applications including treatments outside tumor therapy such as age-related macular degeneration or tissue engineering. In this study, we investigated the antiproliferative effects of fucoidans extracted from six different algae (Fucus vesiculosus, F. serratus, F. distichus subsp. evanescens, Dictyosiphon foeniculaceus, Laminaria digitata, Saccharina latissima) as well as three reference compounds (Sigma fucoidan, heparin, enoxaparin) on tumor (HL-60, Raji, HeLa, OMM-1, A-375, HCT-116, Hep G2) and non-tumor (ARPE-19, HaCaT) cell lines. All fucoidans were extracted according to a standardized procedure and tested in a commercially available MTS assay. Cell viability was measured after 24 h incubation with test compounds (1–100 µg/mL). Apart from few exceptions, fucoidans and heparins did not impair cell viability. In contrast, fucoidans significantly increased cell viability of suspension cell lines, but not of adherent cells. Fucoidans slightly increased viability of tumor cells and had no impact on the viability of non-tumor cells. The cell viability of HeLa and ARPE-19 cells negatively correlated with protein content and total phenolic content (TPC) of fucoidans, respectively. In summary, none of the tested fucoidans turned out to be anti-proliferative, rendering them interesting for future studies and applications.

Document Type: Article
Keywords: Fucus vesiculosus; Fucus serratus; Fucus evanescens; Laminaria digitata; Saccharina latissima; Dictyosiphon foeniculaceus; heparin; cancer; cytotoxic; antiproliferative
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MN Marine natural products chemistry
Refereed: Yes
Open Access Journal?: Yes
DOI etc.: 10.3390/md17080441
ISSN: 1660-3397
Projects: FucoSan
Date Deposited: 29 Jul 2019 10:46
Last Modified: 06 Feb 2020 09:16

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