Bioactive Carbon-Based Hybrid 3D Scaffolds for Osteoblast Growth.

Taale, Mohammadreza, Schütt, Fabian, Zheng, Kai, Mishra, Yogendra Kumar, Boccaccini, Aldo R., Adelung, Rainer and Selhuber-Unkel, Christine (2018) Bioactive Carbon-Based Hybrid 3D Scaffolds for Osteoblast Growth. ACS Applied Materials & Interfaces, 10 (50). pp. 43874-43886. DOI 10.1021/acsami.8b13631.

Full text not available from this repository.

Supplementary data:


Bone, nerve, and heart tissue engineering place high demands on the conductivity of three-dimensional (3D) scaffolds. Fibrous carbon-based scaffolds are excellent material candidates to fulfill these requirements. Here, we show that highly porous (up to 94%) hybrid 3D framework structures with hierarchical architecture, consisting of microfiber composites of self-entangled carbon nanotubes (CNTs) and bioactive nanoparticles are highly suitable for growing cells. The hybrid 3D structures are fabricated by infiltrating a combination of CNTs and bioactive materials into a porous (∼94%) zinc oxide (ZnO) sacrificial template, followed by the removal of the ZnO backbone via a H2 thermal reduction process. Simultaneously, the bioactive nanoparticles are sintered. In this way, conductive and mechanically stable 3D composites of free-standing CNT-based microfibers and bioactive nanoparticles are formed. The adopted strategy demonstrates great potential for implementing low-dimensional bioactive materials, such as hydroxyapatite (HA) and bioactive glass nanoparticles (BGN), into 3D carbon-based microfibrous networks. It is demonstrated that the incorporation of HA nanoparticles and BGN promotes the biomineralization ability and the protein adsorption capacity of the scaffolds significantly, as well as fibroblast and osteoblast adhesion. These results demonstrate that the developed carbon-based bioactive scaffolds are promising materials for bone tissue engineering and related applications.

Document Type: Article
Keywords: carbon nanotubes, 3D scaffolds, bioactive glass, hydroxyapatite
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1021/acsami.8b13631
ISSN: 1944-8244
Projects: Future Ocean
Date Deposited: 01 Aug 2019 10:08
Last Modified: 02 Jan 2020 12:21

Actions (login required)

View Item View Item