Linear and cyclic peptides from the entomopathogenic bacterium Xenorhabdus nematophilus.

Lang, Gerhard, Kalvelage, Tim, Peters, Arne, Wiese, Jutta and Imhoff, Johannes F. (2008) Linear and cyclic peptides from the entomopathogenic bacterium Xenorhabdus nematophilus. Journal of Natural Products, 72 . pp. 1074-1077. DOI 10.1021/np800053n.

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Three new peptides, xenortides A and B and xenematide, were isolated from a culture of the nematode-associated entomopathogenic bacterium Xenorhabdus nematophilus. Their structures were elucidated using NMR, MS, and chemical derivatization methods. Xenortides A and B are the N-phenethylamide and tryptamide derivatives, respectively, of the dipeptide (NMe-L-Leu-NMe-L-Phe). The cyclodepsipeptide xenematide has the sequence (Thr-Trp-Trp-Gly), with a 2-phenylacetamide substituent at the threonine residue and one D-tryptophan. The new peptides and the two known compounds xenocoumacin II and nematophin were tested for antibacterial, antifungal, insecticidal, and anti-Artemia salina activities. Xenematide and xenocoumacin II showed moderate antibacterial activities. Xenocoumacin II, nematophin, and the two xenortides were active in the Artemia salina assay, and xenematide acted weakly

Document Type: Article
Additional Information: WOS:000257227200031
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1021/np800053n
ISSN: 0163-3864
Projects: Future Ocean
Date Deposited: 03 Dec 2008 16:52
Last Modified: 04 May 2018 09:41

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