Cladobotric acids A-F, new cytotoxic polyketides from a New Zealand Cladobotryum sp..

Mitova, Maya I., Lang, Gerhard, Blunt, J. W., Cummings, N. J., Cole, A. L. J., Robinson, W. T. and Munro, M. H. G. (2006) Cladobotric acids A-F, new cytotoxic polyketides from a New Zealand Cladobotryum sp.. Journal of Organic Chemistry, 71 (2). pp. 492-497. DOI 10.1021/jo051883l.

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Abstract

Cladobotric acids A−F (1−6), fungal-derived polyketides, were isolated from the fermentation broth of a New Zealand Cladobotryum species. Structures were determined by extensive spectral analysis and X-ray crystallography, and the polyketide origin of 1−6 was concluded from feeding experiments with 13C-labeled precursors. The observed folding pattern for the polyketide chain is unusual for fungi. Cladobotric acids A−F (1−6) exhibited notable cytotoxicity against the murine P388 leukemia cell line and were also active against Bacillus subtilis and Candida albicans.

Document Type: Article
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1021/jo051883l
ISSN: 0022-3263
Date Deposited: 03 Dec 2008 16:51
Last Modified: 05 Oct 2017 13:37
URI: http://oceanrep.geomar.de/id/eprint/7204

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