Subinhibitory concentrations of antibiotics induce phenazine production in a marine Streptomyces sp.

Mitova, Maya I., Lang, Gerhard, Wiese, Jutta and Imhoff, Johannes F. (2008) Subinhibitory concentrations of antibiotics induce phenazine production in a marine Streptomyces sp. Journal of Natural Products, 71 . pp. 824-827. DOI 10.1021/np800032a.

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Abstract

Subinhibitory concentrations of antibiotics were found to enhance and modulate the production of new phenazines, streptophenazines A-H, in a marine Streptomyces isolate. The streptophenazines differ in length and substitution of an alkyl chain. The pattern of metabolites formed depends on the antibiotic used. In the presence of tetracycline, streptophenazines F and G were induced and the production of streptophenazines A-D was increased. When using bacitracin, mainly streptophenazine H was produced. Streptophenazines C and H showed moderate activity against Bacillus subtilis, while streptophenazine C was also active against Staphylococcus lentus.

Document Type: Article
Additional Information: WOS:000256180600017
Keywords: SPONGE-ASSOCIATED BACTERIA
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1021/np800032a
ISSN: 0163-3864
Projects: Future Ocean
Date Deposited: 03 Dec 2008 16:52
Last Modified: 30 Apr 2018 12:33
URI: http://oceanrep.geomar.de/id/eprint/7879

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