Pteratides I-IV, New Cytotoxic Cyclodepsipeptides from the Malaysian Basidiomycete Pterula sp..

Chen, C.-H., Lang, Gerhard, Mitova, Maya I., Murphy, A. C., Cole, A. L. J., Din, L. B., Blunt, J. W. and Munro, M. H. G. (2006) Pteratides I-IV, New Cytotoxic Cyclodepsipeptides from the Malaysian Basidiomycete Pterula sp.. Journal of Organic Chemistry, 71 (13). pp. 7947-7951. DOI 10.1021/jo060843u.

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Abstract

Four new cyclodepsipeptides, pteratides I−IV (1−4), have been isolated from the extract of a Pterula species collected from a Malaysian tropical forest. Homonuclear and heteronuclear 2D NMR techniques as well as MS fragmentation experiments, in combination with methanolysis, determined the gross structures of the peptides and showed that pteratides I and II each contained the nonproteinogenic amino acid 4-methylproline. The absolute configurations of the amino acids in pteratides I−IV were established using Marfey's method. Pteratides I and II are each potently cytotoxic against the P388 murine leukemia cell line (IC50 values of 41 and 40 nM, respectively). Pteratides III and IV show weaker, but still notable, activity with IC50 values of 7.4 and 2.9 μM, respectively.

Document Type: Article
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1021/jo060843u
ISSN: 0022-3263
Date Deposited: 03 Dec 2008 16:51
Last Modified: 06 Oct 2017 06:55
URI: http://oceanrep.geomar.de/id/eprint/8181

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