A role for membrane-bound CD147 in NOD2-mediated recognition of bacterial cytoinvasion.

Till, A., Rosenstiel, Philip, Braeutigam, K., Sina, C., Jacobs, G., Oberg, H. H., Seegert, D., Chakraborty, T. and Schreiber, Stefan (2008) A role for membrane-bound CD147 in NOD2-mediated recognition of bacterial cytoinvasion. Journal of Cell Science, 121 (4). pp. 487-495. DOI 10.1242/jcs.016980.

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Abstract

NOD2 is an intracellular receptor for the bacterial cell wall component muramyl dipeptide. Mutations in the leucine-rich repeat region of NOD2, which lead to an impaired recognition of muramyl dipeptide, have been associated with chronic inflammatory diseases of barrier organs such as Crohn disease, asthma and atopic eczema. In this study we identify CD147 (also known as BSG and EMMPRIN), a membrane-bound regulator of cellular migration, differentiation and inflammatory processes, as a protein interaction partner of NOD2. We demonstrate a complex influence of the CD147-NOD2 interaction on NOD2-dependent signaling responses. We show that CD147 itself acts as an enhancer of the invasion of Listeria monocytogenes, an intracellular bacterial pathogen. We propose that the CD147-NOD2 interaction serves as a molecular guide to regulate NOD2 function at sites of pathogen invasion.

Document Type: Article
Keywords: Inflammation, Crohn disease, Protein interaction, CD147 (BSG, EMMPRIN), NOD2 (CARD15), Cytoinvasion, Listeria monocytogenes
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: No
Publisher: The Company of Biologists
Projects: Future Ocean
Date Deposited: 12 Oct 2010 10:54
Last Modified: 13 Jun 2019 15:35
URI: https://oceanrep.geomar.de/id/eprint/9152

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