Uncovering the evolutionary history of innate immunity: The simple metazoan Hydra uses epithelial cells for host defence.

Bosch, T. C. G., Augustin, R., Anton-Erxleben, F., Fraune, Sebastian, Hemmrich, G., Zill, H., Rosenstiel, Philip, Jacobs, G., Schreiber, Stefan, Leippe, M., Stanisak, M., Grotzinger, J., Jung, S., Podschun, R., Bartels, J., Harder, J. and Schroder, J. M. (2009) Uncovering the evolutionary history of innate immunity: The simple metazoan Hydra uses epithelial cells for host defence. Developmental and Comparative Immunology, 33 (4). pp. 559-569. DOI DOI:10.1016/j.dci.2008.10.004.

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Abstract

Although many properties of the innate immune system are shared among multicellular animals, the evolutionary origin remains poorly understood. Here we characterize the innate immune system in Hydra, one of the simplest multicellular animals known. In the complete absence of both protective mechanical barriers and mobile phagocytes, Hydra's epithelium is remarkably well equipped with potent antimicrobial peptides to prevent pathogen infection. Induction of antimicrobial peptide production is mediated by the interaction of a leucine-rich repeats (LRRs) domain containing protein with a TIR-domain containing protein lacking LRRs. Conventional Toll-like receptors (TLRs) are absent in the Hydra genome. Our findings support the hypothesis that the epithelium represents the ancient system of host defence. (C) 2008 Elsevier Ltd. All rights reserved.

Document Type: Article
Keywords: Innate immunity; Epithelial defence; Antimicrobial peptides; Toll-like receptors; Hydra
Research affiliation: Kiel University
Kiel University > Kiel Marine Science
UNSPECIFIED
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: DOI:10.1016/j.dci.2008.10.004
ISSN: 0145-305X
Projects: Future Ocean
Date Deposited: 11 Feb 2011 12:15
Last Modified: 08 Feb 2018 12:59
URI: http://oceanrep.geomar.de/id/eprint/9308

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