Increased Mycophenolic Acid Exposure in Stable Kidney Transplant Recipients on Tacrolimus as Compared With Those on Sirolimus: Implications for Pharmacokinetics.

Braun, F., Schocklmann, H., Ziegler, E., Kunzendorf, Ulrich, Armstrong, V. W. and Renders, L. (2009) Increased Mycophenolic Acid Exposure in Stable Kidney Transplant Recipients on Tacrolimus as Compared With Those on Sirolimus: Implications for Pharmacokinetics. Clinical Pharmacology & Therapeutics, 86 (4). pp. 411-415.

Full text not available from this repository.

Abstract

The pharmacokinetics of mycophenolic acid (MPA) was studied in 23 kidney transplant recipients with stable, long-term graft function who were receiving mycophenolate mofetil (MMF) in combination with either tacrolimus or sirolimus therapy. After 500 mg MM F, the mean MPA area under the curve (AUC) was significantly lower in sirolimus-treated patients than in those treated with tacrolimus (35.4 +/- 32.3 vs. 77.1 +/- 67.5 mg/l). MPA peak plasma concentration (C-max) and MPA trough plasma concentration (C-min) were significantly higher in patients who received tacrolimus than in those who received sirolimus. There were no significant differences between the two groups with respect to MPA time to maximum concentration (T-max), MPA-glucuronide (MPAG) AUC, MPAG C-max, MPAG C-min, MPAG T-max, MPA-acyl-glucuronide (AcMPAG) AUC, AcMPAG C-max, AcMPAG C-min, and AcMPAG T-max. In conclusion, MPA exposure is greater in tacrolimus-treated patients than in those treated with sirolimus during maintenance immunosuppression after kidney transplant. It is suggested that the influence of tacrolimus on the pharmacokinetics of MPA reflects an interaction of the two agents at the level of their intestinal absorption.

Document Type: Article
Keywords: renal-allograft recipientssolid-organ transplantation wound-healing complications clinical pharmacokinetics glucuronide metabolite acute rejection risk-factors human plasma mofetil cyclosporine
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
?? med ??
Refereed: Yes
ISSN: 0009-9236
Projects: Future Ocean
Date Deposited: 11 Feb 2011 12:15
Last Modified: 14 Sep 2016 09:34
URI: http://oceanrep.geomar.de/id/eprint/9314

Actions (login required)

View Item View Item