Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible.

Hutchinson, J. A., Govert, F., Riquelme, P., Brasen, J. H., Brem-Exner, B. G., Matthai, M., Schulze, M., Renders, L., Kunzendorf, Ulrich, Geissler, E. K. and Fandrich, F. (2009) Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible. Clinical Transplantation, 23 (1). pp. 140-145. DOI 10.1111/j.1399-0012.2008.00953.x.

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Abstract

Patient KW, a 36-yr-old male renal transplant recipient, received transplant acceptance-inducing cells (TAICs) as an adjunct immunosuppressive therapy. In the weeks post-transplantation, the patient's conventional immunosuppressive treatment was gradually minimized, such that, from the 21st wk post-transplantation onwards, the patient was stably maintained on tacrolimus monotherapy. Treatment with TAICs was without complication, both at the time of administration and in the four-yr follow-up period. It is concluded that the production and administration of TAICs to recipients of kidney transplants from deceased donors is technically feasible.

Document Type: Article
Keywords: cell-based immunotherapyregulatory macrophage tacrolimus monotherapy stem-cells immunosuppression macrophages induction tolerance spleen rat repopulation kinetics
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1111/j.1399-0012.2008.00953.x
ISSN: 0902-0063
Projects: Future Ocean
Date Deposited: 11 Feb 2011 12:16
Last Modified: 29 Jul 2019 06:57
URI: http://oceanrep.geomar.de/id/eprint/9468

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