Kinship testing goes linkage.

Krawczak, Michael and Nothnagel, M. (2009) Kinship testing goes linkage. Annals of Human Genetics, 73 . p. 665. DOI 10.1002/9780470015902.a0005453.pub2.

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In kinship testing, the level of genotypic similarity between individuals at suitable genetic markers is utilised to assess their degree of familial relationship. Inference is made either by evaluating the available genotypic information under different hypotheses about kinship, represented by different pedigree structures, or through the direct quantification of kinship coefficients using a statistical approach. One complicating factor in genetic kinship testing, however, is population structure whereby the assumption of statistical independence between genotypes of unrelated individuals, or between genotypes at unlinked markers, may become violated. Similarly, physical linkage between markers can also render the simple, so‐called ‘product rule’ for composite likelihood calculation invalid. In these instances, specific statistical approaches and computer algorithms need to be used that properly adjust the relevant computations for population structure or linkage.

Document Type: Article
Additional Information: Part 6505VL
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1002/9780470015902.a0005453.pub2
ISSN: 0003-4800
Projects: Future Ocean
Date Deposited: 11 Feb 2011 12:15
Last Modified: 24 Sep 2019 00:18

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