Association of HTRA1 and ARMS2 gene variation with drusen formation in rhesus macaques.

Singh, K. K., Krawczak, Michael, Dawson, W. W. and Schmidtke, J. (2009) Association of HTRA1 and ARMS2 gene variation with drusen formation in rhesus macaques. Experimental Eye Research, 88 (3). pp. 479-482. DOI 10.1016/j.exer.2008.10.019.

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Age-related macular degeneration (AMD) is a clinically heterogeneous disease and constitutes the major cause of visual impairment in the elderly population worldwide. Rhesus macaques also possess a macula and, like humans, develop drusen-associated, age-related macular pathologies. Susceptibility to AMD in humans and drusen formation in rhesus macaques both have been shown to be associated with variation in the HTRA1 and ARMS2 genes. To corroborate these results we genotyped a cohort of 116 rhesus macaques with and without macular drusen. Like in humans, markers in the two genes showed a significant association with drusen formation at the genotype level. joint haplotype analysis revealed, however, that the disease association observed in rhesus macaques was entirely attributable to a promoter polymorphism (-5586>T) of the HTRA1 gene. 2008 Elsevier Ltd. All rights reserved.

Document Type: Article
Keywords: rhesus macaquemacular degeneration drusen formation disease-gene association macular degeneration macaca-mulatta susceptibility monkeys disease
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1016/j.exer.2008.10.019
ISSN: 0014-4835
Projects: Future Ocean
Date Deposited: 11 Feb 2011 12:15
Last Modified: 04 Jan 2017 13:48

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