Association of UCP2-866 G/A polymorphism with chronic inflammatory diseases

Yu, X., Wieczorek, S., Franke, A., Yin, H., Pierer, M., Sina, C., Karlsen, T. H., Boberg, K. M., Bergquist, A., Kunz, M., Witte, T., Gross, W. L., Epplen, J. T., Alarcon-Riquelme, M. E., Schreiber, Stefan and Ibrahim, S. M. (2009) Association of UCP2-866 G/A polymorphism with chronic inflammatory diseases Genes and Immunity, 10 (6). pp. 601-605. DOI 10.1038/gene.2009.29.

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Supplementary data:

Abstract

We reported earlier that two mitochondrial gene polymorphisms, UCP2 -866 G/A (rs659366) and mtDNA nt13708 G/A (rs28359178), are associated with multiple sclerosis ( MS). Here we aim to investigate whether these functional polymorphisms contribute to other eight chronic inflammatory diseases, including rheumatoid arthritis ( RA), systemic lupus erythematosus (SLE), Wegener' granulomatosis (WG), Churg-Strauss syndrome (CSS), Crohn's disease ( CD), ulcerative colitis (UC), primary sclerosing cholangitis (PSC) and psoriasis. Compared with individual control panels, the UCP2-866 G/A polymorphism was associated with RA and SLE, and the mtDNA nt13708 G/A polymorphism with RA. Compared with combined controls, the UCP2-866 G/A polymorphism was associated with SLE, WG, CD and UC. When all eight disease panels and the original MS panel were combined in a meta-analysis, the UCP2 was associated with chronic inflammatory diseases in terms of either alleles ( odds ratio ( OR) = 0.91, 95% confidence interval ( 95% CI): 0.86-0.96), P = 0.0003) or genotypes ( OR = 0.88, ( 95% CI: 0.82-0.95), P = 0.0008), with the -866A allele associated with a decreased risk to diseases. As the -866A allele increases gene expression, our findings suggest a protective role of the UCP2 protein in chronic inflammatory diseases. Genes and Immunity ( 2009) 10, 601-605; doi:10.1038/gene.2009.29; published online 23 April 2009

Document Type: Article
Keywords: mitochondria, chronic inflammatory diseases, uncoupling protein 2
Research affiliation: Kiel University > Faculty of Medicine > Institute of Clinical Molecular Biology
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
DOI etc.: 10.1038/gene.2009.29
ISSN: 1466-4879
Date Deposited: 03 Jan 2011 12:35
Last Modified: 19 Apr 2013 12:25
URI: http://oceanrep.geomar.de/id/eprint/9859

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