Langkocyclines: novel angucycline antibiotics from Streptomyces sp. Acta 3034*.

Kalyon, Bahar, Tan, Geok-Yuan A., Pinto, John M., Foo, Cheau-Yee, Wiese, Jutta , Imhoff, Johannes F. , Süssmuth, Roderich D., Sabaratnam, Vikineswary and Fiedler, Hans-Peter (2013) Langkocyclines: novel angucycline antibiotics from Streptomyces sp. Acta 3034*. The Journal of Antibiotics, 66 (10). pp. 609-616. DOI 10.1038/ja.2013.53.

[thumbnail of ja201353a.pdf] Text
ja201353a.pdf - Published Version
Restricted to Registered users only

Download (883kB) | Contact

Supplementary data:

Abstract

Langkocyclines A1–A3 and B1 and B2, five new angucycline antibiotics produced by Streptomyces sp. Acta 3034, were detected in the course of our HPLC-diode array screening. The producing strain was isolated from the rhizospheric soil of a Clitorea sp. collected from Burau Bay, Langkawi, Malaysia, and was characterized by morphological, physiological and chemotaxonomic features in addition to 16S ribosomal RNA gene sequence information. Strain Acta 3034 is closely related to Streptomyces psammoticus NBRC 13971T and Streptomyces lanatus NBRC 12787T. Langkocyclines consist of an angular tetracyclic benz[a]anthracene skeleton and hydrolyzable O-glycosidic sugar moieties. The yellow-colored A-type langkocyclines differ in their aglycon from the blue-lilac-colored B-type langkocyclines. The A-type langkocycline aglycon is identical to that of aquayamycin and urdamycin A. The chemical structures of the langkocyclines were elucidated by HR-MS, 1D and 2D NMR experiments. They are biologically active against Gram-positive bacteria and exhibit a moderate antiproliferative activity against various human tumor cell lines.

Document Type: Article
Additional Information: WOS:000326287600004
Keywords: angucyclines; antitumor; Streptomyces; structure elucidation; taxonomy
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
Refereed: Yes
Open Access Journal?: No
Publisher: Japan Antibiotics Research Association ; Nature Publishing Group
Projects: ACTAPHARM, KIWIZ, Future Ocean
Date Deposited: 17 Jul 2013 12:14
Last Modified: 18 Jan 2018 13:42
URI: https://oceanrep.geomar.de/id/eprint/21595

Actions (login required)

View Item View Item