Malettinin E, an antibacterial and antifungal tropolone produced by a marine Cladosporium strain.

Silber, Johanna, Ohlendorf, Birgit, Labes, Antje, Wenzel-Storjohann, Arlette, Näther, Christian and Imhoff, Johannes F. (2014) Malettinin E, an antibacterial and antifungal tropolone produced by a marine Cladosporium strain. Open Access Frontiers in Marine Science, 1 (35). DOI 10.3389/fmars.2014.00035.

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The isolation and structure elucidation of malettinins A–C (1–3) along with the new malettinin E (4) are described. The compounds were produced by the fungus Cladosporium sp. strain KF501, which was isolated from the German Wadden Sea. The malettinins are built up of tropolone/dihydropyran ring structures linked to a furan ring. The structure elucidation of the isolated compounds was achieved by means of one- and two-dimensional NMR spectroscopy supported by mass and UV data. The relative configuration of 4 was determined on the basis of single-crystal X-ray diffraction analysis. 1–4 exhibited antibacterial and antifungal activities when profiled against Xanthomonas campestris and Trichophyton rubrum. The influence of the chemical structure of the furan ring and of configurational changes on biological activities was observed.

Document Type: Article
Funder compliance: info:eu-repo/grantAgreement/EC/FP7/265926
Keywords: marinenaturalproducts,fungalnaturalproducts,antibacterial,antifungal, Cladosporium sp., malettinin,tropolone
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
Refereed: Yes
Open Access Journal?: Yes
DOI etc.: 10.3389/fmars.2014.00035
ISSN: 2296-7745
Projects: Future Ocean, Marine Fungi, KIWIZ
Date Deposited: 19 Aug 2014 09:49
Last Modified: 13 Jan 2016 12:25

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