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In vivo effects of deoxynivalenol (DON) on innate immune responses of carp (Cyprinus carpio L.).
Pietsch, Constanze, Michel, Christian, Kersten, Susanne, Valenta, Hana, Dänicke, Sven, Schulz, Carsten, Kloas, Werner and Burkhardt-Holm, Patricia (2014) In vivo effects of deoxynivalenol (DON) on innate immune responses of carp (Cyprinus carpio L.). Food and Chemical Toxicology, 68 . pp. 44-52.
Full text not available from this repository.Abstract
Abstract Deoxynivalenol (DON) is one of the most important members of Fusarium toxins since it often can be found in relevant concentrations in animal feeds. The effects of this group of toxins on fish are mostly unknown. The present study shows results from a feeding trial with carp (Cyprinus carpio L.) using three different concentrations of DON (352 μg kg−1, 619 μg kg−1, and 953 μg kg−1 final feed, respectively) which are comparable to levels found in commercial fish feeds. Effects on growth and mass of fish were not observed during this 6 weeks lasting experiment. Only marginal DON concentrations were found in muscle and plasma samples. Blood parameters were not influenced although smaller erythrocytes occurred in fish treated with 352 μg kg−1 DON. Analysis of antioxidative enzymes in erythrocytes showed increased superoxid dismutase and catalase activities in fish fed the low-dose feed. Immunosuppressive effects of DON were confirmed whereby cytotoxic effects on immune cells only partly explained the impairment of innate immune responses. Exact polarization of the immune system into pro-inflammatory or anti-inflammatory responses due to DON exposure should be clarified in further experiments, especially since the current results raise concern about impaired immune function in fish raised in aquaculture.
Document Type: | Article |
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Keywords: | Mycotoxin Haematology Immune system Aquaculture |
Research affiliation: | Kiel University Kiel University > Kiel Marine Science OceanRep > The Future Ocean - Cluster of Excellence OceanRep > The Future Ocean - Cluster of Excellence > FO-R04 |
Refereed: | Yes |
Open Access Journal?: | No |
Publisher: | Elsevier |
Projects: | Future Ocean |
Date Deposited: | 30 Jan 2017 10:26 |
Last Modified: | 23 Sep 2019 21:25 |
URI: | https://oceanrep.geomar.de/id/eprint/35766 |
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