Lang, Gerhard, Mitova, Maya I., Ellis, G., van der Sar, G.S., Phipps, R.K., Blunt, J.W., Cummings, N.J., Cole, A.L.J. and Munro, M.H.G. (2006) Bioactivity profiling using HPLC/microtitre-plate analysis: application to a New Zealand marine alga-derived fungus, Gliocladium sp.. Journal of Natural Products, 69 . pp. 621-624. DOI 10.1021/np0504917.

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Abstract

Using HPLC/microtiter-plate-based generation of activity profiles the extract of a marine alga-derived fungus, identified as Gliocladium sp., was shown to contain the known strongly cytotoxic metabolite 4-keto-clonostachydiol (1) and also clonostachydiol (2) as well as gliotide (3), a new cyclodepsipeptide containing several d-amino acids. The absolute configuration of 1 was elucidated by reduction to 2, and two further oxidized derivatives of clonostachydiol (5, 6) were prepared and evaluated for biological activity.

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