Eckardt, C., Schmidt, D. and Czank, M. (1990) Intraocular tolerance to silicone oils of different specific gravities. An experimental study. Ophthalmologica, 201 (3). pp. 133-9.

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Abstract

Different methylphenylsilicone (MPS) and fluorosilicone (FS) oils having a higher specific gravity than water were investigated as vitreous replacements. Their intraocular tolerance in vitrectomized aphakic rabbit eyes was evaluated for periods of up to 4 months and compared to that of regular polydimethylsilicone oil (PDMS). Weakly fluorinated FS and weakly phenylated MPS showed a presumably toxic effect on the retina. As compared to highly fluorinated FS, highly phenylated MPS showed better intraocular tolerance; however, inflammatory reaction was slightly more extensive than in eyes filled with PDMS.

Document Type:	Article
Additional Information:	Eckardt, C Schmidt, D Czank, M Comparative Study Switzerland Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde Ophthalmologica. 1990;201(3):133-9.
Keywords:	Animals Corneal Edema/chemically induced/pathology Dimethylpolysiloxanes/toxicity Follow-Up Studies Inflammation/chemically induced/pathology Iris/drug effects/pathology Rabbits Retina/*drug effects/pathology Retinal Detachment/chemically induced/pathology Silicone Oils/*toxicity Silicones/toxicity Siloxanes/toxicity Specific Gravity *Vitrectomy
Research affiliation:	Kiel University
Refereed:	No
Date Deposited:	02 Feb 2012 07:44
Last Modified:	23 Sep 2019 16:54
URI:	https://oceanrep.geomar.de/id/eprint/15510

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