Auinger, A., Helwig, U., Pfeuffer, M., Rubin, D., Luedde, M., Rausche, T., El Mokhtari, N. E., Folsch, U. R., Schreiber, Stefan, Frey, N. and Schrezenmeir, J. (2012) A variant in the heart-specific fatty acid transport protein 6 is associated with lower fasting and postprandial TAG, blood pressure and left ventricular hypertrophy. British Journal of Nutrition, 107 (10). pp. 1422-1428.

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Abstract

Fatty acid transport protein 6 (FATP6) is primarily expressed in the heart and seems to be involved in cardiac fatty acid uptake. Therefore, we investigated whether a variation in the 5'-untranslated region of the FATP6 gene is associated with features of the metabolic syndrome and signs of myocardial alteration or heart failure. A total of 755 male participants from a Metabolic Intervention Cohort Kiel were genotyped for the FATP6-7T > A polymorphism (rs2526246) and phenotyped for features of the metabolic syndrome. Participants underwent a glucose tolerance test and the postprandial assessment of metabolic variables after a standardised mixed meal. Left ventricular heart function was evaluated in fifty-four participants. Fasting (P=0.01) and postprandial (P=0.02) TAG concentrations were significantly lower in AA homozygotes when compared with wild-type carriers. Homozygosity of allele A was associated with significantly lower postprandial insulin concentrations after a glucose load and significantly lower systolic (P=0-01) and diastolic (P=0.01) blood pressure values compared with wild-type carriers. Accordingly, left ventricular heart mass was significantly lower in twenty-seven AA homozygotes in comparison with twenty-seven IT homozygotes, matched for BMI (P=0.04). In conclusion, the effects of the FATP6 polymorphism on TAG are mediated by affluent dietary fat, The FATP6-7T > A polymorphism may protect from traits of the metabolic syndrome and CVD.

Document Type:	Article
Additional Information:	Fed Res Inst Nutr & Food, Dept Microbiol & Biotechnol, Max Rubner Inst, D-24103 Kiel, Germany. Fed Res Inst Nutr & Food, Dept Physiol & Biochem Nutr, Max Rubner Inst, D-24103 Kiel, Germany. Univ Hosp Schleswig Holstein UKSH, Dept Med 1, Clin Gen Internal Med, D-24105 Kiel, Germany. Fed Res Inst Nutr & Food, Dept Physiol & Biochem Nutr, Max Rubner Inst, D-76131 Karlsruhe, Germany. Clin Res Ctr Kiel, D-24118 Kiel, Germany. Univ Hosp Schleswig Holstein UKSH, Dept Cardiol, D-24105 Kiel, Germany. Auinger, A (reprint author), Fed Res Inst Nutr & Food, Dept Microbiol & Biotechnol, Max Rubner Inst, Hermann Weigmann Str 1, D-24103 Kiel, Germany. annegret.auinger@mri.bund.de
Keywords:	Metabolic syndrome Cardiac hypertrophy Genetic variant Fatty acid transport protein lipoprotein-lipase glucose-metabolism gene-expression insulin sensitivity skeletal-muscle cardiomyopathy triglycerides deficiency resistance failure
Research affiliation:	OceanRep > The Future Ocean - Cluster of Excellence Kiel University
Projects:	Future Ocean
Date Deposited:	14 May 2014 10:24
Last Modified:	23 Sep 2019 18:36
URI:	https://oceanrep.geomar.de/id/eprint/23799

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