Aden, K., Zeuner, R., Schreiber, Stefan, Rosenstiel, Philip and Schroeder, J. O. (2014) The role of gut microbiota in rheumatoid arthritis and its modulation by anti TNF alpha agents - implications for the predicition of therapy response?. Zeitschrift Fur Rheumatologie, 73 . p. 13. DOI 10.3390/jcm6060060.

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Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease, caused by both genetic and environmental factors. Recently, investigators have focused on the gut microbiota, which is thought to be an environmental agent affecting the development of RA. Here we review the evidence from animal and human studies that supports the role of the gut microbiota in RA. We and others have demonstrated that the abundance of Prevotella copri is increased in some early RA. We have also used gnotobiotic experiments to show that dysbiosis in RA patients contributed to the development of Th17 cell-dependent arthritis in intestinal microbiota-humanized SKG mice. On the other hand, Prevotella histicola from human gut microbiota suppressed the development of arthritis. In summary, Prevotella species are involved in the pathogenesis of arthritis.

Document Type:	Article
Additional Information:	Times Cited: 0 1 Aden, Konrad/H-1477-2014 0
Keywords:	rheumatoid arthritis; microbiota; Prevotella copri; gut; Th17 cell
Research affiliation:	Kiel University Kiel University > Kiel Marine Science OceanRep > The Future Ocean - Cluster of Excellence
Refereed:	Yes
Open Access Journal?:	No
Publisher:	MDPI
Projects:	Future Ocean
Date Deposited:	30 Mar 2015 11:55
Last Modified:	23 Sep 2019 22:17
URI:	https://oceanrep.geomar.de/id/eprint/27100

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