Schreiber, Stefan, Nikolaus, S. and Rosenstiel, Philip (2014) Microbiome and nutrition. The way to a future therapy for chronic inflammatory bowel diseases?. Internist, 55 (8). 889-+. DOI 10.1007/s00108-013-3443-0.

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Abstract

The complex microbiome of the human gut contains an excessive amount of genetic information that is more than 100-fold larger than the human genome. In patients with inflammatory bowel disease diversity of the gut microbiome is significantly reduced and moreover specific phyla are overrepresented or underrepresented. However, the functional capacity of the microflora to generate certain metabolic products containing lipids or amino acids- and more complex regulatory substances is more important that the mere annotation of the microorganisms. Modern pharmacological approaches target the functional capacity and constitution of the microbiome. An important strategy is the development of controlled release formulations that deliver defined lipid, carbohydrate or amino acid products derived from nutritional components targeting gut areas distal to the absorption zones of the upper gastrointestinal tract.

Document Type:	Article
Additional Information:	Times Cited: 0 0
Keywords:	Crohn‘s disease, Colitis, ulcerative, Immunonutrition, Probiotics, Inflammation
Research affiliation:	Kiel University Kiel University > Kiel Marine Science OceanRep > The Future Ocean - Cluster of Excellence
Refereed:	Yes
Open Access Journal?:	No
Publisher:	American Medical Association
Projects:	Future Ocean
Date Deposited:	30 Mar 2015 12:44
Last Modified:	23 Sep 2019 21:04
URI:	https://oceanrep.geomar.de/id/eprint/28189

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