Wettwer, Erich and Terlau, Heinrich (2014) Pharmacology of voltage-gated potassium channel K(v)1.5-impact on cardiac excitability. Current Opinion in Pharmacology, 15 . pp. 115-121.

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Abstract

Voltage activated potassium (K-v) channels are intensely investigated targets within the pharmacological strategies to treat cardiac arrhythmia. For atrial fibrillation (AF) substances inhibiting the ultra rapid outward rectifying K current (l(Kur)) and its underlying K(v)1.5 channel have been developed. Here we describe potential limitations of this approach with respect to critical parameters of K channel pharmacology. In healthy tissue l(kur)/K(v)1.5 inhibition can unexpectedly lead to action potential shortening with corresponding arrhythmogenic effects. In tissue with chronic AF, electrical remodeling occurs which is accompanied with changes in ion channel expression and composition. As a consequence atrial tissue exhibits a different pharmacological fingerprint. New strategies to obtain more mechanistic insight into drug target interaction are needed for better understanding the pharmacological potential of l(Kur)/K(v)1.5 inhibition for AF treatment.

Document Type:	Article
Additional Information:	Times Cited: 0 0
Research affiliation:	Kiel University > Kiel Marine Science
Refereed:	Yes
Date Deposited:	30 Mar 2015 12:53
Last Modified:	01 Feb 2018 11:22
URI:	https://oceanrep.geomar.de/id/eprint/28349

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