Yang, Wentao, Dierking, Katja, Esser, Daniela, Tholey, Andreas, Leippe, Matthias, Rosenstiel, Philip and Schulenburg, Hinrich (2015) Overlapping and unique signatures in the proteomic and transcriptomic responses of the nematode Caenorhabditis elegans toward pathogenic Bacillus thuringiensis. Developmental and Comparative Immunology, 51 (1). pp. 1-9. DOI 10.1016/j.dci.2015.02.010.

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Abstract

Pathogen infection can activate multiple signaling cascades that ultimately alter the abundance of molecules in cells. This change can be measured both at the transcript and protein level. Studies analyzing the immune response at both levels are, however, rare. Here, we compare transcriptome and proteome data generated after infection of the nematode and model organism Caenorhabditis elegans with the Gram-positive pathogen Bacillus thuringiensis. Our analysis revealed a high overlap between abundance changes of corresponding transcripts and gene products, especially for genes encoding C-type lectin domain-containing proteins, indicating their particular role in worm immunity. We additionally identified a unique signature at the proteome level, suggesting that the C. elegans response to infection is shaped by changes beyond transcription. Such effects appear to be influenced by AMP-activated protein kinases (AMPKs), which may thus represent previously unknown regulators of C. elegans immune defense. (C) 2015 The Authors. Published by Elsevier Ltd.

Document Type:	Article
Additional Information:	Times Cited: 4
Keywords:	Innate immunity, C-type lectins, Proteomics, RNA-Seq, Caenorhabditis elegans, Bacillus thuringiensis
Research affiliation:	Kiel University Kiel University > Kiel Marine Science OceanRep > The Future Ocean - Cluster of Excellence
Refereed:	Yes
Open Access Journal?:	No
Publisher:	Elsevier
Projects:	Future Ocean
Date Deposited:	18 Oct 2016 03:46
Last Modified:	23 Sep 2019 21:18
URI:	https://oceanrep.geomar.de/id/eprint/32766

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