Baumgart, D. C., Bokemeyer, B., Drabik, A., Stallmach, A., Schreiber, Stefan and Vedolizumab Germany, Consortium (2016) Vedolizumab induction therapy for inflammatory bowel disease in clinical practice - a nationwide consecutive German cohort study. Alimentary Pharmacology & Therapeutics, 43 (10). pp. 1090-1102. DOI 10.1111/apt.13594.

Full text not available from this repository.

Abstract

Background Vedolizumab (VDZ) is a humanised monoclonal IgG1 antibody targeting alpha(4)beta(7) integrin. Aim To investigate the real-world efficacy of vedolizumab for the treatment of Crohn's disease (CD) and ulcerative colitis (UC). Methods A consecutive cohort of 212 adult IBD patients with active disease (HBI > 7/ partial Mayo > 4) newly receiving VDZ was prospectively recruited from 7 academic and 17 community centres. The primary endpoint was clinical remission (CRM) (CD HBI <= 4, UC pMayo < 1) in week 14. Secondary endpoints included steroid-free remission (SFCRM), clinical response (CRS) (HBI/pMayo score drop = 3), vedolizumab impact on CRP, calprotectin and haemoglobin. Results Data of 97 CD (71.1% female, HBI 11) and 115 UC (42.6% female, pMayo 6) patients were analysed. Only 5.2% CD and 24.3% UC were anti-TNF alpha naive. Most had extensive mucosal involvement (Montreal L3 69.1%/E3 53.9%). At week 14, 23.7% vs. 23.5% of CD vs. UC patients achieved CRM, 19.6% vs. 19.1% SFCRM and 60.8% vs. 57.4% CRS, respectively (all based on NRI). Week 14 CRM in CD was significantly associated with no history of extraintestinal manifestations (P = 0.019), no prior adalimumab use (P = 0.011), no hospitalisation in the past 12 months (P = 0.015) and low HBI score (P = 0.02) and in UC with active or previous smoking (P = 0.044/0.028) and no anti-TNFa (P = 0.023) use. Low HBI (P = 0.019) and no hospitalisation in the past 12 months (P = 0.01) predict CD CRM. The three most common AE were joint pain, acne and nasopharyngitis. Conclusion Vedolizumab is effective in routine use.

Document Type:	Article
Additional Information:	Times Cited: 4 Baumgart, D. C. Bokemeyer, B. Drabik, A. Stallmach, A. Schreiber, S.
Research affiliation:	Kiel University OceanRep > The Future Ocean - Cluster of Excellence
Refereed:	Yes
Open Access Journal?:	No
Publisher:	John Wiley & Sons: Blackwell Publishing
Projects:	Future Ocean
Date Deposited:	19 Mar 2017 07:50
Last Modified:	23 Sep 2019 20:31
URI:	https://oceanrep.geomar.de/id/eprint/36007

Actions (login required)

View Item