Bogumil, David and Dagan, Tal (2012) Cumulative Impact of Chaperone-Mediated Folding on Genome Evolution. Biochemistry, 51 (50). pp. 9941-9953. DOI 10.1021/bi3013643.

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Abstract

Molecular chaperones support protein folding and unfolding along with assembly and translocation of protein complexes. Chaperones have been recognized as important mediators between an organismal genotype and phenotype as well as important maintainers of cellular fitness under environmental conditions that induce high mutational loads. Here we review recent studies revealing that the folding assistance supplied by chaperones is evident in genomic sequences implicating chaperone-mediated folding as an influential factor during protein evolution. Interaction of protein with chaperones ensures a proper folding and function, yet an adaptation to obligatory dependence on such assistance may be irreversible, representing an evolutionary trap. A correlation between the requirement for a chaperone and protein expression level indicates that the evolution of substrate–chaperone interaction is bounded by the required substrate abundance within the cell. Accumulating evidence suggets that the utility of chaperones is governed by a delicate balance between their help in mitigating the risks of protein misfolding and aggregate formation on one hand and the slower rate of protein maturation and the energetic cost of chaperone synthesis on the other.

Document Type:	Article
Research affiliation:	Kiel University
Refereed:	Yes
Date Deposited:	24 Mar 2017 10:00
Last Modified:	24 Mar 2017 10:00
URI:	https://oceanrep.geomar.de/id/eprint/37144

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