Parrot, Delphine, Legrave, Nathalie, Intertaglia, Laurent, Rouaud, Isabelle, Legembre, Patrick, Grube, Martin, Suzuki, Marcelino T. and Tomasi, Sophie (2016) Cyaneodimycin, a Bioactive Compound Isolated from the Culture ofStreptomyces cyaneofuscatusAssociated withLichina confinis. European Journal of Organic Chemistry, 2016 (23). pp. 3977-3982. DOI 10.1002/ejoc.201600252.

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Abstract

Two new compounds, cyaneodimycin (1) and cyaneomycin (2) bearing a rare methacrylate residue, were isolated from cultures of the bacterium Streptomyces cyaneofuscatus associated with the marine lichen Lichina confinis. These astonishing structures may be derived from a pyruvate biosynthetic pathway. Cyaneodimycin (1) exhibited antiproliferative properties against B16 (IC50 = 27 ± 4 µm), HaCaT (IC50 = 47 ± 11 µm) and Jurkat cell lines (IC50 = 18.5 ± 0.5 µm). Six known compounds 3–8 with diversified structures and interesting biological properties (diketopiperazines, actinomycin, dibenzofurane or indole derivatives) were isolated jointly with compounds 1 and 2. Among them, usnic acid (8), a common lichen compound was isolated for the first time from bacteria.

Document Type:	Article
Refereed:	Yes
Date Deposited:	13 Jun 2017 10:20
Last Modified:	01 Feb 2019 15:07
URI:	https://oceanrep.geomar.de/id/eprint/38353

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