Zidorn, Christian, Petersen, Bent O., Sareedenchai, Vipaporn, Ellmerer, Ernst P. and Duus, Jens Ø. (2010) Tragoponol, a dimeric dihydroisocoumarin from Tragopogon porrifolius L.. Tetrahedron Letters, 51 (10). pp. 1390-1393. DOI 10.1016/j.tetlet.2010.01.016.

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Abstract

A phytochemical re-investigation of Tragopogon porrifolius L. (Asteraceae) yielded (7S,15S)-2,4,12-trihydroxy-7-(4-hydroxyphenyl)-10-methoxy-15-(4-methoxyphenyl)-7,8,15,16-tetrahydrodibenzo[c,i][1,7]dioxacyclododecine-5,13-dione, named tragoponol, a dimeric dihydroisocoumarin.

The compound, which represents the first of its kind, is comprised of the open-chained forms of two different mono-methoxylated dihydroisocoumarin moieties, scorzocreticin and hongkongenin, which are connected via two ester bonds to form a macrolide with two lactone moieties featuring a 12-membered ring. The structure of the nearly symmetrical compound was established by HR mass spectrometry, CD measurements, and extensive 1D and 2D NMR experiments.

Document Type:	Article
Refereed:	Yes
Date Deposited:	29 Jun 2017 14:32
Last Modified:	29 Jun 2017 14:32
URI:	https://oceanrep.geomar.de/id/eprint/38697

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