Nasajpour, A., Mandla, S., Shree, S., Mostafavi, E., Sharifi, R., Khalilpour, A., Saghazadeh, S., Hassan, S., Mitchell, M. J., Leijten, J., Hou, X., Moshaverinia, A., Annabi, N., Adelung, Rainer, Mishra, Y. K., Shin, S. R., Tamayol, A. and Khademhosseini, A. (2017) Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. Nano Letters, 17 (10). pp. 6235-6240. DOI 10.1021/acs.nanolett.7b02929.

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Abstract

Nanoparticles have been used for engineering composite materials to improve the intrinsic properties and/or add functionalities to pristine polymers. The majority of the studies have focused on the incorporation of spherical nanoparticles within the composite fibers. Herein, we incorporate anisotropic branched-shaped zinc oxide (ZnO) nanoparticles into fibrous scaffolds fabricated by electrospinning. The addition of the branched particles resulted in their protrusion from fibers, mimicking the architecture of a rose stem. We demonstrated that the encapsulation of different-shape particles significantly influences the physicochemical and biological activities of the resultant composite scaffolds. In particular, the branched nanoparticles induced heterogeneous crystallization of the polymeric matrix and enhance the ultimate mechanical strain and strength. Moreover, the three-dimensional (3D) nature of the branched ZnO nanoparticles enhanced adhesion properties of the composite scaffolds to the tissues. In addition, the rose stem-like constructs offered excellent antibacterial activity, while supporting the growth of eukaryote cells.

Document Type:	Article
Keywords:	antimicrobial; Branched tetrapod nanoparticles; electrospinning; nanocomposites; scaffolds; zinc oxide
Research affiliation:	Kiel University > Kiel Marine Science OceanRep > The Future Ocean - Cluster of Excellence
Refereed:	Yes
Open Access Journal?:	Yes
Publisher:	American Chemical Society
Date Deposited:	12 Dec 2017 13:33
Last Modified:	09 May 2019 09:13
URI:	https://oceanrep.geomar.de/id/eprint/40545

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