Sommer, Felix, Rühlemann, Malte Christoph, Bang, Corinna, Höppner, Marc, Rehman, Ateequr, Kaleta, Christoph, Schmitt-Kopplin, Phillippe, Dempfle, Astrid, Weidinger, Stephan, Ellinghaus, Eva, Krauss-Etschmann, Susanne, Schmidt-Arras, Dirk, Aden, Konrad, Schulte, Dominik, Ellinghaus, David, Schreiber, Stefan, Tholey, Andreas, Rupp, Jan, Laudes, Matthias, Baines, John F, Rosenstiel, Philip and Franke, Andre (2017) Microbiomarkers in inflammatory bowel diseases: caveats come with caviar. Gut, 66 (10). pp. 1734-1738. DOI 10.1136/gutjnl-2016-313678.

Full text not available from this repository.

Abstract

View the most recent version of this article
PDF

Leading article
Microbiomarkers in inflammatory bowel diseases: caveats come with caviar
Felix Sommer1, Malte Christoph Rühlemann1, Corinna Bang1, Marc Höppner1, Ateequr Rehman1, Christoph Kaleta2, Phillippe Schmitt-Kopplin3, Astrid Dempfle4, Stephan Weidinger5, Eva Ellinghaus1, Susanne Krauss-Etschmann2,6, Dirk Schmidt-Arras7, Konrad Aden1, Dominik Schulte8, David Ellinghaus1, Stefan Schreiber1,8, Andreas Tholey2, Jan Rupp9, Matthias Laudes8, John F Baines2,10, Philip Rosenstiel1, Andre Franke1
Author affiliations
View Full Text
http://dx.doi.org/10.1136/gutjnl-2016-313678

Statistics from Altmetric.com
Article has an altmetric score of 55
See more details

Blogged by 1
Tweeted by 71
On 2 Facebook pages
32 readers on Mendeley
The largest numbers of commensal bacteria reside within our intestinal tract, with an increasing density from mouth to anus. Recently, a new estimate for the total number of bacteria (3.8×1013) in the 70 kg ‘reference man’ was reported.1 For human cells, the same authors revised past estimates to 3.0×1013 cells, out of which approximately 90% belong to the haematopoietic lineage. Hence, the widely cited 10:1 ratio of bacteria versus human cells received an update, showing that the number of bacteria in the body is actually of the same order as the number of human cells, and that the cumulative bacterial mass is about 200 g. Still, this large number of bacteria highlights their importance in maintaining health and metabolism. Different parts of the intestinal tract have different functions, tissue structure varies accordingly and gradients exist for several physicochemical parameters such as nutrients, pH or oxygen levels.2 Consequently, microbiota composition varies along the gut, but also between luminal and mucosa-attached communities of the same intestinal segment, and even along the crypt-villus axis in the epithelium. Thus, host–microbiota interactions are likely regionally specific and the local crosstalk determines intestinal function and physiology. Probably each human individual carries its own ‘microbial fingerprint’ (especially when considering genomic variation within the bacterial species’ populations), which is why forensic scientists started to exploit the use of this non-human organ.

Document Type:	Article
Keywords:	Biostatistics; Crohn's Disease; Intestinal Microbiology
Research affiliation:	Kiel University > Kiel Marine Science OceanRep > The Future Ocean - Cluster of Excellence Kiel University
Refereed:	Yes
Open Access Journal?:	No
Publisher:	American Association for the Advancement of Science (AAAS)
Projects:	Future Ocean
Date Deposited:	08 Jan 2018 11:07
Last Modified:	12 Apr 2019 14:44
URI:	https://oceanrep.geomar.de/id/eprint/41252

Actions (login required)

View Item