Klimovich, Alexander, Rehm, Arvid, Wittlieb, Jörg, Herbst, Eva-Maria, Benavente, Ricardo and Bosch, T. C. G. (2018) Non-senescent Hydra tolerates severe disturbances in the nuclear lamina. Aging, 10 . DOI 10.18632/aging.101440.

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Abstract

The cnidarian Hydra is known for its unlimited lifespan and non-senescence, due to the indefinite self-renewal capacity of its stem cells. While proteins of the Lamin family are recognized as critical factors affecting senescence and longevity in human and mice, their putative role in the extreme longevity and non-senescence in long-living animals remains unknown. Here we analyze the role of a single lamin protein in non-senescence of Hydra. We demonstrate that proliferation of stem cells in Hydra is robust against the disturbance of Lamin expression and localization. While Lamin is indispensable for Hydra, the stem cells tolerate overexpression, downregulation and mislocalization of Lamin, and disturbances in the nuclear envelope structure. This extraordinary robustness may underlie the indefinite self-renewal capacity of stem cells and the non-senescence of Hydra. A relatively low complexity of the nuclear envelope architecture in basal Metazoa might allow for their extreme lifespans, while an increasing complexity of the nuclear architecture in bilaterians resulted in restricted lifespans.

Document Type:	Article
Keywords:	non-senescence, stem cell, lamin, nuclear envelope, Hydra
Research affiliation:	Kiel University > Kiel Marine Science OceanRep > The Future Ocean - Cluster of Excellence Kiel University
Refereed:	Yes
Open Access Journal?:	No
Publisher:	Klimovich et al.
Projects:	Future Ocean
Date Deposited:	31 Jul 2018 10:45
Last Modified:	02 Apr 2019 09:20
URI:	https://oceanrep.geomar.de/id/eprint/43855

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