Seidel, Ulrike, Baumhof, Elena, Hägele, Franziska A., Bosy‐Westphal, Anja, Birringer, Marc and Rimbach, Gerald (2019) Lithium‐Rich Mineral Water is a Highly Bioavailable Lithium Source for Human Consumption. Molecular Nutrition & Food Research . p. 1900039. DOI 10.1002/mnfr.201900039.

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Abstract

Scope
Lithium is an important trace element in human nutrition and medicine. Mineral and medicinal waters may represent a significant source of dietary lithium intake.
Methods and results
The lithium concentration of 360 German mineral and 21 medicinal waters is determined. Based on a systematic screening, three different mineral waters exhibiting low (1.7 µg L−1), medium (171 µg L−1), and high lithium (1724 µg L−1) concentrations are chosen for an acute bioavailability study in male healthy volunteers. In Germany, a north‐east to south‐west gradient of analyzed lithium concentrations is observed in the 381 tested waters. The lithium concentration in the water is significantly correlated with its sodium (r = 0. 810), potassium (r = 0.716), and magnesium (r = 0.361), but not with its calcium concentration. In a randomized cross‐over trial, volunteers (n = 3×10 each) drink 1.5 L of the respective mineral waters, and lithium concentrations in serum and urine are monitored over 24 h. Consumption of the mineral waters with a medium and high lithium content results in a dose‐dependent response in serum lithium concentrations and total urinary lithium excretion.
Conclusion
Lithium‐rich mineral and medicinal waters may be an important and highly bioavailable lithium source for human consumption.

Document Type:	Article
Research affiliation:	Kiel University > Kiel Marine Science OceanRep > The Future Ocean - Cluster of Excellence Kiel University
Refereed:	Yes
Open Access Journal?:	No
Publisher:	American Medical Association
Date Deposited:	13 Aug 2019 10:12
Last Modified:	02 Jan 2020 12:24
URI:	https://oceanrep.geomar.de/id/eprint/47482

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