Characterisation of gene variations in the transcription T-bet and HLX1 and their functional role in the development of asthma.

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Suttner, K., Rosenstiel, Philip, Depner, M., Ruoss, I., Peters, W., Klopp, N., Illig, T., Vogelberg, C., Weiland, S. K., von Mutius, E. and Kabesch, M. (2008) Characterisation of gene variations in the transcription T-bet and HLX1 and their functional role in the development of asthma. Journal of Allergy and Clinical Immunology, 121 (2). p. 246. DOI 10.1016/j.jaci.2007.12.255.

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Abstract

The transcription factors T-bet and HLX1 play an important role in T cell development by inducing Th1 differentiation and by suppressing Th2 commitment, crucial mechanisms in asthma and allergy. Thus, it was speculated that genetic variations in both genes may lead to a deregulation of the immune system and therefore contributing to the development of these diseases.

Document Type: Article
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: No
Publisher: Elsevier
Projects: Future Ocean
Date Deposited: 12 Oct 2010 11:26
Last Modified: 28 Jul 2019 04:24
URI: https://oceanrep.geomar.de/id/eprint/9146

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