Fuchs, H., Gailus-Durner, V., Adler, T., Pimentel, J. A. A., Becker, L., Bolle, I., Brielmeier, M., Calzada-Wack, J., Dalke, C., Ehrhardt, N., Fasnacht, N., Ferwagner, B., Frischmann, U., Hans, W., Holter, S. M., Holzlwimmer, G., Horsch, M., Javaheri, A., Kallnik, M., Kling, E., Lengger, C., Maier, H., Mossbrugger, I., Morth, C., Naton, B., Noth, U., Pasche, B., Prehn, C., Przemeck, G., Puk, O., Racz, I., Rathkolb, B., Rozman, J., Schable, K., Schreiner, R., Schrewe, A., Sina, C., Steinkamp, R., Thiele, F., Willershauser, M., Zeh, R., Adamski, J., Busch, D. H., Beckers, J., Behrendt, H., Daniel, H., Esposito, I., Favor, J., Graw, J., Heldmaier, G., Hofler, H., Ivandic, B., Katus, H., Klingenspor, M., Klopstock, T., Lengeling, A., Mempel, M., Muller, W., Neschen, S., Ollert, M., Quintanilla-Martinez, L., Rosenstiel, Philip, Schmidt, J., Schreiber, Stefan, Schughart, K., Schulz, H., Wolff, E., Wurst, W., Zimmer, A. and de Angelis, M. H. (2009) The German Mouse Clinic: A Platform for Systemic Phenotype Analysis of Mouse Models. Current Pharmaceutical Biotechnology, 10 (2). pp. 236-243. DOI 10.2174/138920109787315051.

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Abstract

The German Mouse Clinic (GMC) is a large scale phenotyping center where mouse mutant lines are analyzed in a standardized and comprehensive way. The result is an almost complete picture of the phenotype of a mouse mutant line - a systemic view. At the GMC, expert scientists from various fields of mouse research work in close cooperation with clinicians side by side at one location. The phenotype screens comprise the following areas: allergy, behavior, clinical chemistry, cardiovascular analyses, dysmorphology, bone and cartilage, energy metabolism, eye and vision, hostpathogen interactions, immunology, lung function, molecular phenotyping, neurology, nociception, steroid metabolism, and pathology. The German Mouse Clinic is an open access platform that offers a collaboration-based phenotyping to the scientific community (www.mouseclinic.de). More than 80 mutant lines have been analyzed in a primary screen for 320 parameters, and for 95% of the mutant lines we have found new or additional phenotypes that were not associated with the mouse line before. Our data contributed to the association of mutant mouse lines to the corresponding human disease. In addition, the systemic phenotype analysis accounts for pleiotropic gene functions and refines previous phenotypic characterizations. This is an important basis for the analysis of underlying disease mechanisms. We are currently setting up a platform that will include environmental challenge tests to decipher genome-environmental interactions in the areas nutrition, exercise, air, stress and infection with different standardized experiments. This will help us to identify genetic predispositions as susceptibility factors for environmental influences.

Document Type:	Article
Keywords:	lung-functionmice strains susceptibility mutagenesis generation mutants isolate genome tool
Research affiliation:	OceanRep > The Future Ocean - Cluster of Excellence Kiel University
Refereed:	Yes
Open Access Journal?:	No
Publisher:	Bentham Science
Projects:	Future Ocean
Date Deposited:	11 Feb 2011 12:14
Last Modified:	29 Jul 2019 07:41
URI:	https://oceanrep.geomar.de/id/eprint/9396

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