Tregouet, D. A., Konig, I. R., Erdmann, J., Munteanu, A., Braund, P. S., Hall, A. S., Grosshennig, A., Linsel-Nitschke, P., Perret, C., DeSuremain, M., Meitinger, T., Wright, B. J., Preuss, M., Balmforth, A. J., Ball, S. G., Meisinger, C., Germain, C., Evans, A., Arveiler, D., Luc, G., Ruidavets, J. B., Morrison, C., van der Harst, P., Schreiber, Stefan, Neureuther, K., Schafer, A., Bugert, P., El Mokhtari, N. E., Schrezenmeir, J., Stark, K., Rubin, D., Wichmann, H. E., Hengstenberg, C., Ouwehand, W., Ziegler, A., Tiret, L., Thompson, J. R., Cambien, F., Schunkert, H., Samani, N. J., Wellcome Trust Case Control, Consor and Cardiogenics, Consortium (2009) Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nature Genetics, 41 (3). pp. 283-285. DOI 10.1038/ng.314.

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Abstract

We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

Document Type:	Article
Keywords:	apolipoprotein(a) genemyocardial-infarction lipoprotein(a) levels heart-disease polymorphisms ectim
Research affiliation:	Kiel University OceanRep > The Future Ocean - Cluster of Excellence
Refereed:	Yes
Open Access Journal?:	No
Publisher:	Nature Publishing Group
Projects:	Future Ocean
Date Deposited:	11 Feb 2011 12:14
Last Modified:	23 Sep 2019 23:00
URI:	https://oceanrep.geomar.de/id/eprint/9788

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