Brötz, Elke, Kulik, Andreas, Vikineswary, Sabaratnam, Lim, Chew-Theng, Tan, Geok Yuan Annie, Zinecker, Heidi, Imhoff, Johannes F. , Paululat, Thomas and Fiedler, Hans-Peter (2011) Phenelfamycins G and H, new elfamycin-type antibiotics produced by Streptomyces albospinus Acta 3619. The Journal of Antibiotics, 64 (3). pp. 257-266. DOI 10.1038/ja.2010.170.

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Abstract

Phenelfamycins G and H are new members of the family of elfamycin antibiotics with the basic structure of phenelfamycins E and F, respectively, which are also well known as ganefromycins α and β. Phenelfamycins G and H differ from phenelfamycins E and F by an additional hydroxy group at position C-30, which is not described so far for any of the elfamycin-type antibiotics. The actinomycete strain that produced phenelfamycins G and H was identified to be Streptomyces albospinus based on its 16S rRNA gene sequence. Phenelfamycins G and H exhibit a narrow antibacterial spectrum with a pronounced inhibitory activity against Propionibacterium acnes.

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