Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp. NTK 935.

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Nachtigall, Jonny, Schneider, Kathrin, Bruntner, Christina, Bull, Alan T, Goodfellow, Michael, Zinecker, Heidi, Imhoff, Johannes F. , Nicholson, Graeme, Irran, Elisabeth, Süssmuth, Roderich D and Fiedler, Hans-Peter (2011) Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp. NTK 935. The Journal of Antibiotics, 64 (6). pp. 453-457. DOI 10.1038/ja.2011.26.

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Abstract

Benzoxacystol, a new 1,4-benzoxazine-type metabolite, was produced by strain NTK 935, a marine member of the Streptomyces griseus 16S rRNA clade, isolated from deep-sea sediment collected from the Canary Basin. The structure of benzoxacystol was determined by mass spectrometry, NMR experiments and X-ray analysis. The compound showed an inhibitory activity against the enzyme glycogen synthase kinase 3β and a weak antiproliferative activity against mouse fibroblast cells.

Document Type: Article
Keywords: Microbiology; 1,4-benzoxazin-3-one; glycogen synthase kinase 3β; marine Streptomyces
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
Refereed: Yes
Open Access Journal?: No
Publisher: Japan Antibiotics Research Association ; Nature Publishing Group
Projects: Future Ocean
Date Deposited: 25 Aug 2011 12:46
Last Modified: 23 Sep 2019 20:19
URI: https://oceanrep.geomar.de/id/eprint/12043

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