Nachtigall, Jonny, Kulik, Andreas, Helaly, Soleiman, Bull, Alan T, Goodfellow, Michael, Asenjo, Juan A, Maier, Armin, Wiese, Jutta , Imhoff, Johannes F. , Süssmuth, Roderich D and Fiedler, Hans-Peter (2011) Atacamycins A–C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38*. The Journal of Antibiotics, 64 . pp. 775-780. DOI 10.1038/Ja.2011.96.

Text 2011_Nachtigall_etal_Imhoff_ja201196a.pdf - Published Version Restricted to Registered users only Download (369kB) | Contact

Abstract

Three new 22-membered macrolactone antibiotics, atacamycins A-C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells

Actions (login required)

View Item