Elaiomycins K and L, new azoxy antibiotics from Streptomyces sp. Tü 6399*.

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Manderscheid, Niko, Helaly, Soleiman E, Kulik, Andreas, Wiese, Jutta , Imhoff, Johannes F. , Fiedler, Hans-Peter and Süssmuth, Roderich D. (2013) Elaiomycins K and L, new azoxy antibiotics from Streptomyces sp. Tü 6399*. The Journal of Antibiotics, 66 . pp. 85-88. DOI 10.1038/ja.2012.99.

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Abstract

Elaiomycins K and L, two new azoxy-type antibiotics, were detected by HPLC-diode array screening in the culture filtrate extract of Streptomyces sp. Tü 6399. The structures were determined by high-resolution MS and 2-dimensional (1)H and (13)C correlated NMR spectroscopy including (15)N-NMR experiments and established these compounds as new members of the elaiomycin family. Both metabolites show a weak antibacterial activity against Bacillus subtilis and Staphylococcus lentus as well as against the phytophathogenic strain Xanthomonas campestris

Document Type: Article
Keywords: antibacterial; azoxy antibiotics; Streptomyces; structural determination
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
Refereed: Yes
Open Access Journal?: No
Publisher: Japan Antibiotics Research Association ; Nature Publishing Group
Projects: KIWIZ, Future Ocean
Date Deposited: 04 Dec 2012 13:33
Last Modified: 18 Jan 2018 13:44
URI: https://oceanrep.geomar.de/id/eprint/19535

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