Warkmycin, a novel angucycline antibiotic produced by Streptomyces sp. Acta 2930.

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Helaly, S. E., Goodfellow, M., Zinecker, Heidi, Imhoff, Johannes F. , Süssmuth, R. D. and Fiedler, H.-P. (2013) Warkmycin, a novel angucycline antibiotic produced by Streptomyces sp. Acta 2930. Journal of Antibiotics, 66 (11). pp. 669-674. DOI 10.1038/ja.2013.74.

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Abstract

A novel angucycline-type antibiotic, warkmycin, was isolated from the culture filtrate of Streptomyces strain Acta 2930. Its chemical structure was elucidated by HR-MS, one-dimensional and 2D NMR experiments. The compound inhibits the growth of Gram-positive bacteria and shows a strong antiproliferative activity against mouse fibroblast cell line NIH-3T3 and human cancer cell lines HepG2 and HT29.

Document Type: Article
Additional Information: WOS:000327677600007
Keywords: Streptomyces sp. Acta 2930
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
Refereed: Yes
Open Access Journal?: No
Publisher: JAPAN ANTIBIOTICS RESEARCH ASSOC
Projects: KIWIZ, Future Ocean
Date Deposited: 25 Apr 2013 13:21
Last Modified: 23 Sep 2019 17:36
URI: https://oceanrep.geomar.de/id/eprint/21167

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